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stragalus membranaceus (Fisch.) Bge.(Huang Chi), has many functions to improve our health, and then we describe its benefits later. I .Huang Chi can raise human's immune force. Scientists' results may have
important implications for our understanding on the molecular mechanisms
of immunopotentiating polysaccharides from Astragalus membranaceus
(40). The immunopotentiating effect of the roots of Astragalus
membranaceus , a medicinal herb, has been associated with its
polysaccharide fractions (Astragalus polysaccharides, APS). We herein
demonstrate that APS activates mouse B cells and macrophages, but not T
cells, in terms of proliferation or cytokine production(1). Huangqi (Astragalus
membranaceus), a traditional Chinese medicine, has been used to
ameliorate side effects of cancer chemotherapy in China. The prospect of
inducing expression of adult (beta) globin gene and apoptosis
selectively in cancer cells is obviously attractive from a therapeutic
point of view(5). Regaining the immunity function of rats with low
immunity after feeding the aqueous extract of the hairy roots produced
by large-scale culture showed that its capacity was similar to the dry
roots of A. membranaceus in increasing the immunity function.
The results in this paper give evidence that the hairy roots may be a
new source of A. membranaceus (19, 5). Scientists' data indicate
that AM is an effective immune modulator, capable of potentiating in
vitro the antitumor activity of rIL-2-generated LAK cells(23).
Astragalus membranaceus (AM) and Ligustrum lucidum (LL)
have previously been shown to modulate immune response. Data from this
study suggest that they may also exert their antitumor activity via
abolition of tumor-associated macrophage suppression(25). Astragalus
membranaceus extracts injected into normal mice or mice immunodepressed
by cyclophosphamide or radiation treatment or by aging are able to
enhance the antibody response to a T-dependent antigen(26). Scientist'
conclude that potentiation of antitumor activity mediated by recombinant
interleukin-2 (rIL-2) in low concentrations is possible by the
concomitant use of another immune modulator such as Astragalus
membranaceus(30). These preclinical data also provide the rational basis
for the use of extracts of Astragalus membranaceus in phase I
clinical trials among patients suffering from iatrogenic or inherent
immune deficiency states(31). The in vitro immunomodulatory activity of
fractions derived from Astragalus membranaceus, an herb commonly used in
the practice of traditional Chinese medicine, was first screened by
studying their individual effects on mononuclear cells (MNC) derived
from healthy normal donors using the local xenogeneic graft-versus-host
reaction (XGVHR)(32). Astragalosides have the effects on reducing
[Ca2+]i and SR Ca2+ load, enhancing free radical removal and decreasing
lipid peroxidation in ISO-treated cardiomyocytes, which might account
for their protective effect on myocardial injury(42). Although glucan
did not improve pig performance under the conditions of the present
experiment, when included at 500 mg/kg, it decreased the release of
inflammatory cytokine and corticosteroid and improved the lymphocyte
proliferation response of weanling piglets via enhanced IL-2
bioactivity(52).Astragalus membranaceus saponins(AMS) could be safely
used as adjuvant with low or non-haemolytic(50). Astragalus membranaceus
possesses both preventive and therapeutic potential in experimental
colitis. The anti-inflammatory actions involve anti-oxidation along with
inhibition of adhesion molecule synthesis in the colonic tissues(49).
Astragalus membranaceus can improve antioxidative effect and regulate
NO/ET level during hemorrhagic reperfusion(48).a polysaccharide isolated
from the roots of Astragalus membranaceus (APS) stimulates macrophages
to express iNOS gene through the activation of NF-kappaB/Rel (47). II . It has anti-oxidized ability to protect normal cells and reduces the risk of cardiovascular disease. Astragaloside IV treatment also decreased the levels of malondialdehyde, an indicator of lipid peroxidation, and increased the levels of the antioxidant enzymes glutathione peroxidase and superoxide dismutase in ischemic tissues. The results presented here provide the first evidence of a neuroprotective effect of Astragaloside IV in the model of ischemic brain injury.Scientist' suggest that the anti-infarction effect by Astragaloside IV may be derived at least in part from its antioxidant properties(2). 'Dang-Gui Decoction for Enriching the Blood' (BE), a traditional Chinese formulation comprising Angelica sinensis and Astragalus membranaceus , is used for stimulating red blood cell production as well as enhancing cardiovascular function. The results suggest that the more potent cardioprotective action of BE preparation (BEA) may be related to its ability to sustain the myocardial glutathione antioxidant status under conditions of IR-induced oxidative stress, which may possibly in turn result from the synergistic interaction between the BE and Polygonum extract. (15,16). Astragalus membranaceus , a Chinese herb, is often used as a "Qi tonifier" and has been studied for its therapeutic benefit in treatment of ischemic heart disease, myocardial infarction, heart failure, and relief of anginal pain. Clinical studies have indicated that its in vitro antioxidant activity is the mechanism by which it affords its cardioprotective benefit(18). In conclusion our data give evidence that in fact astragaloside IV (AS-IV) can increase the fibrinolytic potential of cultured human umbilical vein endothelial cells (HUVECs) not only by upregulating the expression of tissue-type plasminogen activator (t-PA) as NG-R1 does, but also by downregulating the expression of plasminogen activator inhibitor type 1(PAI-1)(20). AM could inhibit the replication of coxsackie B-3 virus(CVB3-RNA), but its effect on CVB3-RNA replication had no correlation with induction of beta-IFN(21). AM should be valuable in preventing and treating acute myocarditis caused by Coxsackie B virus(28,29). Based on the favorable pharmacokinetic properties in both rats and dogs, astragaloside IV warrants further investigation for the prevention of cardiovascular diseases(60).Beneficial effects of Astragalus and Perindopril for treating viral myocarditis might be partly mediated by preserving the functions of SERCA 2 activity and ET system(54).potential roles of antioxidative and nitric oxide-inducing properties of astragaloside IV in its protection from myocardial ischemia(53).Astrapterocarpan inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and that this effect may be mediated, at least in part, by inhibition of the ERK1/2 MAP kinase cascade(51). III .It also protects human's liver not to be damaged by chemistry. AM has been widely used for treating liver diseases in traditional Chinese medicine. Experimental evidence indicates that it has antitumor potential. In this study, the effect of AM on hepatocarcinogenesis induced by diethylnitrosamine (DEN), two-thirds partial hepatectomy, and 2-acetylaminofluorene (2-AAF) (DEN-PH-AAF) was evaluated using glutathione S-transferase placenta form (GST-P) as marker(11). Oral administration of an ethanol extract of the root of Astragalus membranaceus alleviated liver injury induced by stilbenemidine. Pre-administration in mice reduced elevated SGPT levels and subacute toxicity of stilbenemidine, decreased pentobarbital-induced loss of righting reflex and protected hepatic cells from pathological changes(27). IV .It not only improves human's weakness and self-sweat, but also helps injured tissue recover well. Moreover, it helps patience recover
well after cerebral vascular accident. It can reduce the risk of
diabetes. AS I has therapeutic effects on several pharmacological
targets in the progress of Diabetic nephropathy (DN) and is a potential
drug for prevention of early DN(3,37). It can balance human's blood
glucose not to change rigorously in the plasma. It is beneficial for
NIDDM patients to regulate their blood glucose for feedback. In vitro
estrogenic activities of Chinese medicinal plants traditionally used for
the management of menopausal symptoms(46). V . Astragalus membranaceus stimulates human sperm motility in vitro(4,24).It decreases the percentage of sterility. VI .It is induction of growth hormone by the roots of Astragalus membranaceus in pituitary cell culture(10). VII . Effects of medicinal herb tea on the smoking cessation and reducing smoking withdrawal symptoms(43). Among these medicinal herbs, Eugenia aromaticum and Astragalus membranaceus Bunge showed the highest antioxidant activity (IC50 of 30.0 microg/mL) and nicotine degradation activity (NDA) (1.81), respectively. VIII. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves(44, 59). Astragalus membranaceus has strong protective effects on free radical-mediated renal tubular damage induced by high-energy shock waves (HESW) and that these effects are superior to the effects of verapamil(44). Astragaloside treatment provided significant protection against shock wave-induced renal oxidative injury(59).
IX .
Hypoglycemic effect of Astragalus
polysaccharide and its effect on PTP1B(45).
Astragalus polysaccharide (APS) enables insulin-sensitizing and hypoglycemic activity at least in part by decreasing the elevated expression and activity of PTP1B in the skeletal muscles of TIIDM rats. X .Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. Astragaloside IV protected endothelial cells from high glucose-induced barrier impairment by inhibiting PKC activation, as well as improving cytoskeleton remodeling(58). Honey Huang Chi's Function It helps human's gastrointestinal function to degest well(37). Attention: If you have inflammation, fevers, and hypertension, don't take it. Consult your physician prior to use if you are pregnant, nursing or taking a blood-thinning medication. Keep out of reach of children(37). |
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